venofer dosing calculator venofer dosing calculator

Venofer must only be administered intravenously either by slow injection or by infusion. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Dosing: (a) Divide calculated total cumulate dose . For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Applies only to oral form of both agents. 2. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Fulminant symptoms include confusion, sensation of passing out, paleness. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. Copyright 1993-2021 Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Do not administer Venofer to patients with evidence of iron overload. Separate dosing of tetracyclines from these products. Modify Therapy/Monitor Closely. Formula for calculating the required dose of iron sucrose 1. Max Dose. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Separate by 2 hr. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Schrier SL, Mentzer WC, Landaw SA. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. . Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Applies only to oral form of both agents. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Administer while the patient is in a reclined or semi-reclined position. Drug class: Iron products. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Information last revised December 2022. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Applies only to oral form of both agents. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Applies only to oral form of both agents. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Dosage form: injection, solution Applies only to oral form of both agents. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. LBW = Lean body weight in kg. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Use Caution/Monitor. Slowing the infusion rate may alleviate symptoms. Avoid or Use Alternate Drug. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Schweiz Med Wochenschr. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Separate by 2 hr. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Avoid or Use Alternate Drug. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Observed Hb = the patients current hemoglobin in g/dl. US residents can call their local poison control center at 1-800-222-1222. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. UpToDate. Minor/Significance Unknown. Reference www.medicines.org.uk Background Separate dosing of tetracyclines from these products. Minor/Significance Unknown. Use Caution/Monitor. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Use Caution/Monitor. Test Dose: Not required. Parenteral iron dextran therapy. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. 1974 Jun;31(6):592-5. Pediatric Patients (2 Years of Age and Older). Either decreases levels of the other by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Use Caution/Monitor. Minor (1)iron sucrose, captopril. Applies only to oral form of both agents. 1990 Feb;24(2):162-6. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. *Administer early during the dialysis session. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. (3) Known hypersensitivity to Venofer. 1 Dosing for patients who weigh less than 50 kg LBW = Lean body weight in kg. By clicking send, you acknowledge that you have permission to email the recipient with this information. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Ren Fail. The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Applies only to oral form of both agents. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Copyright 2021 GlobalRPH - Web Development by. Applies only to oral form of both agents. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. This may be helped by giving the medication more slowly or at a lower dose. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Applies only to oral form of both agents. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] If we don't have the calculator you need then tell us the details and we'll make it for you. an automated flowchart approach. (See also Notes section. Hollands J, Foote E, Rodriguez A. Administer Venofer early during the dialysis session (generally within the first hour). Use alternatives if available. Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. 2015: 763576. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Kidney Int. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. The above information is provided for general Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Applies only to oral form of both agents. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Venofer treatment may be repeated if iron deficiency reoccurs. Use Caution/Monitor. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Use Caution/Monitor. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. You will have to pay for your IV iron. Although the original formula requires the weight in kilograms, values input in lbs are transformed. The iron formulation choice remains for the clinician to make. Assure stable intravenous access to avoid extravasation. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Applies only to oral form of both agents. Included in the iron dextran package insert. Use Caution/Monitor. commonly, these are generic drugs. Use Caution/Monitor. 1988 May;111(5):566-70. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Consult your doctor before breast-feeding. Separate dosing of tetracyclines from these products. No data are available regarding overdosage of Venofer in humans. Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. 1995 Mar-Apr;11(2):163-8. Oral and parenteral products - see background option for oral products. Administer Venofer early during the dialysis session (generally within the first hour). Use Caution/Monitor. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. You can further save the PDF or print it. This site contains information for licensed healthcare professionals in the United States. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Parenteral iron dextran therapy: a review. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. 1982;13(4):309-21. Deferoxamine chelates iron. Applies only to oral form of both agents. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Applies only to oral form of both agents. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. I. Steps on how to print your input & results: 1. 2. Minor/Significance Unknown. Applies only to oral form of both agents. This website is intended for use by US healthcare professionals only. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Monitor for signs and symptoms of hypotension following each Feraheme infusion. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Applies only to oral form of both agents. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Your doctor will do laboratory tests to monitor your response. By using this form you agree with the storage and handling of your data by this website. Applies only to oral form of both agents. [. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. May increase risk of hypotension. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Last updated on Jun 1, 2022. iron sucrose decreases levels of manganese by inhibition of GI absorption. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). . Applies only to oral form of both agents. Pregnancy: Risk Summary-Clinical Considerations. 1970;100(7):301303. Applies only to oral form of both agents. This topic . If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Administer a test INFeD dose prior to the first therapeutic dose. elemental iron (mg/ml) in the product being used: Where C= Venofer treatment may be repeated if iron deficiency reoccurs. This site complies with the HONcode standard for trust- worthy health information: verify here. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Use Caution/Monitor. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. IDA diagnosis is based on full blood examination and on the serum ferritin level. Either increases effects of the other by pharmacodynamic synergism. A: Generally acceptable. Avoid or Use Alternate Drug. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. We comply with the HONcode standard for trustworthy health information. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Avoid or Use Alternate Drug. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Modify Therapy/Monitor Closely. Med J Aust; 193(9):525-32. Slow or stop the infusion if adverse reactions occur. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Venofer may cause clinically significant hypotension. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). *Repeat dose if iron deficiency anemia reoccurs. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Diagnosis and management of iron deficiency anaemia: a clinical update. Fatal reactions have also occurred in situations where the test dose was tolerated. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Use Caution/Monitor. Most Do not administer Venofer to patients with iron overload. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Dose. Crown Rump Length and Nuchal Translucency. Use Caution/Monitor. 2012;2(4):288-335. Feraheme does not contain antimicrobial preservatives. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. commonly, these are "non-preferred" brand drugs. provider for the most current information. iron sucrose increases levels of calcium chloride by enhancing GI absorption. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. 1998 Feb;25(1):65-8. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Anemia. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). gymnema decreases levels of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Applies only to oral form of both agents. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Use Caution/Monitor. Applies only to oral form of both agents. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. iron sucrose increases levels of calcium acetate by enhancing GI absorption. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. 2010; 193(9):525-32. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Baloxavir may bind to polyvalent cations resulting in decreased absorption. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Administer Venofer only intravenously by slow injection or by infusion. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Applies only to oral form of both agents. Applies only to oral form of both agents. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. J Lab Clin Med; 111(5):566-70. Use Caution/Monitor. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Iron deficiency anemia is the type of anemia caused by iron depletion. Objective. https://www.uptodate.com/ (Requires subscription). Minor/Significance Unknown. Am J HealthSyst Pharm 2006;63:731735. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Keep all medical and lab appointments. . Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L).