Looking specifically to heal any damage from steroid Methasterone aka "Superdrol". I think NAC might compete with other amino acids, and would be more effective on an empty stomach. For people with bipolar disorder and depression, NAC may help decrease symptoms and improve overall ability to function. There isnt a daily requirement for NAC or an agreed upon optimal dose for NAC supplements. Really low/no cholesterol diet and TUDCA could cause problems unless you're obese. NAC is a highly versatile nutrient used for a wide variety of health reasons. While food sources are important to avoid a nutrient deficiency, consuming NAC in supplement form ensures your body has the therapeutic levels needed to support more intensive benefits. Any other suggestions other than obviously discontinuing steroids? But even then, such effects are uncommon and an issue of individual variability and sensitivity. While most of these side effects are relatively mild and temporary, it is important to be aware of them before taking NAC. Note that the numbers in parentheses (1, 2, etc.) I have written before about various causes of insomnia and how they can be supported quickly and effectively. Combination with supplements that affect MAO we assume that this is a boosting rather than inhibiting effect can exacerbate the issue. While its safe for most people to take, some drug interactions and negative reactions are possible. Do you have any reasoning for taking at night that you can share? An older study in 468 men with infertility found that supplementing with 600 mg of NAC and 200 mcg of selenium for 26 weeks improved semen quality (30). I have introduced Mag-Mind, as well as, taurine, however they do not seem to be helping him. Glutathione helps to protect cells from toxins and reduce damage caused by free radicals, as well as help build and repair tissue. People with kidney disease or diabetes should speak to their doctor before taking NAC supplements. Several supplements may ease neuropathy symptoms, like vitamin B, fish oil, curcumin, and more. When is the best time to take NAC? - Thesocialselect.com * That said, glutathione precursors (such as NAC) may offer further mood support by helping to increase glutathione levels in the brain.*. There have been many studies of this compound, including neuroimaging studies, and it has been investigated in innumerable disorders depression, bipolar disorder, OCD, PTSD, schizophrenia, addiction, eating disorders, Alzheimers disease, and addiction. After all, much of the crux of healthy skin and graceful aging is grounded in antioxidant protection, and thus, cellular resilience and longevity. For cold and flu, start taking NAC as soon as symptoms appear. One condition that contributes to male infertility is varicocele when veins inside the scrotum become enlarged as a result of free radical damage. NAC is an amino acid, something present in many foods, but supplements give you a higher dose than youd get in your daily diet. What are the benefits of taking NAC? N-acetyl cysteine, the supplement form of cysteine, is an amino acid that helps the body create and use protective antioxidants. AMLA and dandelion are extremely good supps that actively protect from current damage, and the AMLA is good for a lot of things, including blood/platelets, among other things that TUDCA is bad for. It can help lengthen the time to fatigue, meaning that you dont get tired as fast due to NACs ability to manage lactic-acid build-up. In particular, you need to check thatNACdoes not interact with any medicines if you happen to be taking any. You can order yourself a CBC and CMP blood test online (I use Walkinlab), as well as things like cholesterol/triglycerides so that you know where you're at before TUDCA starts quickly and thoroughly impacting your enzymes. https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-018-1845-1. NACs ability to replenish glutathione and regulate brain glutamate levels can boost brain health. Currently, he cannot get his body to fall asleep until 4am and then he wakes naturally by 8am. All rights reserved. It is also thought to have anti-inflammatory and mucolytic (mucus-dissolving) properties. This can lead to damage or destruction of insulin receptors and increase the risk of type 2 diabetes (32). Available over the counter for decades, NAC remains popular among health-conscious individuals looking for dietary support for respiratory health, detoxification, immune support, mood balance, athletic performance and female fertility, among a myriad of other science-backed benefits. Give them a reliable alternative. Sorry for the late reply but just wanted to thank you for such an informative write up. Reddit and its partners use cookies and similar technologies to provide you with a better experience. It can be taken any time of day that is most convenient. The recommended dosage of NAC depends on a persons age, weight, and health condition. In general, NAC is well-tolerated, meaning it's unlikely to cause side effects when consumed at the recommended dosage. Between 6001,800 milligrams of a NAC supplement daily seems to be effective against many conditions; 600-milligram capsules taken two to three times a day is the recommended dosage to start with. I personally find gummy delivery formats of NAC to be a tad paradoxical, given that NAC is fighting oxidants and the sugars in gummies are, well, not!" For example, mbg's daily detox+ is led by glutathione (a master antioxidant in the realm of detox support) and also contains N-acetyl-L-cysteinea vital player in the detoxification process that replenishes antioxidants in the body to promote healthy redox balance. NAC is a key building block precursor for several antioxidants, including "master antioxidant" glutathione. In very high doses any supplement is capable of contributing to liver or kidney problems however, as explained above, generally NAC is considered protective of the liver and kidneys, not a harm to them. And while oxidative stress can affect the skin's natural defense system, the antioxidant actions of NAC and glutathione help support skin health8 by nurturing overall redox balance. While cysteine is found in many high-protein foods, NAC is only obtained from taking supplements or prescription drugs. NAC can relieve symptoms of respiratory conditions by acting as an antioxidant and expectorant, loosening mucus in your air passageways. Consult your doctor to find out whether NAC may be beneficial for your health. We're extremely lucky to have TUDCA available to us OTC. Approximately 15% of all couples trying to conceive are affected by infertility. Doses of about 0.6 grams of NAC daily can be taken orally along with progesterone after week 16 of pregnancy in order to protect against preterm birth recurrence. This is why its recommended as a potential treatment for different disorders resulting from free oxygen radicals, such as liver disease, Alzheimers, Parkinsons and even cancer. Like other amino acid supplements, NAC should be taken either 30 minutes before, or two hours after, eating to avoid competing with Is there a better combination of supplements that would help him fall asleep at a normal hour? In addition to protecting the organs from free radical damage, another use is helping control side effects associated with taking doses of certain medications/drugs, especially acetaminophen. Experts recommend taking an adequate dose for several months and carefully keeping track of its effects on key symptoms this way you know if its helping and how much you need. In addition to relieving COPD and bronchitis, NAC may improve other lung and respiratory tract conditions such as cystic fibrosis, asthma, and pulmonary fibrosis as well as symptoms of nasal and sinus congestion due to allergies or infections (23, 25). Get full access to Outside Learn, our online education hub featuring in-depth nutrition, fitness and adventure courses, and more than 2,000 instructional videos when you People who have bleeding disorders or take blood thinning medications should not take NAC, because it may slow blood clotting (49). NAC is being done away with, so buy it where you can. However, it is always best to work with a certified practitioner or a functional medicine doctor. NAC Supplement For some conditions, higher doses may be necessary. I have trouble with a racing mind and also staying asleep. According to a 2020 scientific review13 from Frontiers, oxidative stress can disrupt the optimal metabolic functioning of fat cells, leading to greater energy stores. Do you have any other suggestions? These include: Additionally, it can be used to help cancer patients overcome the adverse effects associated with certain drugs and treatments. NAC supplements appear to improve both dopamine function and disease symptoms such as tremors (5). Can You Take Sam-E and Nac Together Complete Guide! As bedtime nears, the brain should naturally make a smooth transition from predominantly glutamate to predominantly GABA,the most prevalent inhibitory neurotransmitter in the brain. Studies have shown no maternal or fetal harmful effects of NAC treatment. NAC Kirsten specializes in nutrition, fitness, food, and DIY; her work has been featured in a variety of publications, including eHow, SparkPeople, and international editions of Cosmopolitan. Does the same thing to iron and cholesterol, for example. mercury. For example, Body Kitchen formulatedMega NAC + Quercetin, a double duty formulathat contains a research-backed amount of NAC (600mg) in combination with a proprietary black pepper extract shown to improve absorption by at least 30%, and a second potent antioxidant, quercetin. I'm very fit, but don't do steroids (ventured into TUDCA due to the damage of a couple years plus of every day inactivity and vodka). What's more, the liver and body rely on antioxidants (such as glutathione) to metabolize and remove heavy metals, according to the International Journal of Molecular Sciences6. New comments cannot be posted and votes cannot be cast. Be cautious if you have legitimate issues with platelets, HDL, or iron. THE EFFECTS OF EMOTIONAL STRESS REDUCED BY NIACIN *, The brain is highly susceptible to oxidative stress10, but prioritizing your body's antioxidant levels can protect it for years to come. Your email address will not be published. From what I read from the article I mentioned in my earlier comment, is that whatever you do it's recommended not to go beyond 1,500mg per day. Could someone just take GABA? "The NAC has made a huge difference in suffering with allergies and breathing issues i have been dealing with"- Christopher, For joint health, flexibility & range of motion. But can that make insomnia worse? This includes what you eat and drink, of course, as well as your personalized supplement lineup. My liver enzymes have only been abnormal once, and after a month and a half, AST/ALT were back around 20 when re-checked, and my gallbladder-like problems were seemingly gone. Cysteine is found in most high protein foods, such as chicken, turkey, yogurt, cheese, eggs, sunflower seeds, and legumes. In fact, doctors regularly give intravenous NAC to people with an acetaminophen overdose to prevent or reduce kidney and liver damage (5). Speak with a doctor if you have any concerns about taking this supplement. If these side effects occur, they are usually mild and resolve on their own with continued use of the supplement. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. "This science also directly supported the full-potency 600-milligram dose of NAC you'll find in mbg's daily detox+. Helping your clients to get quick relief increases their confidence in you as a practitioner and also their faith in their own ability to feel better and be truly well. It seems that it was the last missing piece in my liver support stack, BTW, this was a good read about TUDCA What Is TUDCA and Why Does it Matter to My Health? The most important N-acetyl cysteine mechanisms of action are its antioxidant and anti-inflammatory effects. I always use Oregon Wild Harvest's blend usually for just 2 months whenever I run through some milk thistle, which has been 2 or 3 times a year. When it comes to promoting detoxification, what is N-acetyl cysteine good for? Alas, we are not able to provide any personalized recommendations in this venue. To become wildly satisfied clients, they need to see major results and fast. In other words, as a precursor of L-cysteine, which results in glutathione biosynthesis,NAC (along with glutamine and glycine) is an amino acid that is needed to produce whats arguably the most important antioxidant in the human body. NAC supplements are available in capsule or tablet form, and they can be taken with or without food. If you take pro-biotics, they should be taken on an empty stomach. While NAC is considered safe as a prescription medication, it can cause nausea, vomiting, and gastrointestinal disturbances, as well as mouth issues if inhaled. It is also recommended to introduce the supplements sequentially in order to avoid adverse effects. Create an account to follow your favorite communities and start taking part in conversations. However, like all supplements, NAC can also have some side effects. As an antioxidant, NAC helps replenish glutathione levels in your lungs and reduces inflammation in your bronchial tubes and lung tissue.